داروی آمپی سیلین از داروهای آنتی بیوتیک دسته آمینوپنی سیلین ها بوده و بصورت تزریقی استفاده می شود. توضیحات کامل مربوط به این دارو از جمله اندیکاسیون، دوز تجویز، عوارض جانبی، منع مصرف و … در این مقاله ارائه شده است.
انواع داروی آمپی سیلین
Injectable: Ampicillin sodium 250 mg, 500 mg powders for reconstitution (human licensed product only); 100 mg/ml long-acting preparation
Oral: 250 mg capsule
نحوه عملکرد آمپی سیلین
Binds to penicillin-binding proteins involved in bacterial cell wall synthesis, thereby decreasing cell wall strength and rigidity, affecting cell division, growth and septum formation. It acts in a time-dependent fashion.
موارد مصرف آمپی سیلین در سگ و گربه
Active against many Gram-positive and Gram-negative aerobic organisms and obligate anaerobes, but not against those that produce penicillinases (beta-lactamases), e.g. Escherichia coli, Staphylococcus aureus. The difficult Gram-negative organisms such as Pseudomonas aeruginosa and Klebsiella are usually resistant.
Excreted well in bile and urine. Maintaining levels above the MIC is critical for efficacy and thereby prolonged dosage intervals or missed doses can compromise therapeutic response.
Dose and dosing interval is determined by infection site, severity and organism. Oral bioavailability is reduced in the presence of food.
دوز تجویز آمپی سیلین در سگ و گربه
Routine infections (Dogs, Cats): 10–20 mg/kg i.v., i.m., s.c., p.o. q6–8h.
CNS or serious bacterial infections (Dogs): up to 40 mg/kg i.v. q6h has been recommended.
Diseases:
Canine distemper
Bordetella_bronchiseptica
منابع:
کتاب BSAVA Small Animal Formulary, Part A: Canine and Feline 10th edition انتشار 2020
